All Phenotypes Phf6<em1Wencc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280785
cn2	Phf6^em1Wencc/Y Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280786

Allelic Composition	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6^em1Wencc mutation (0 available); any Phf6 mutation (12 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

hematopoietic system

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

hematopoietic system

hematopoietic system phenotype ( J:278804 )

N	• normal white blood cell count (WBC) at age 8 weeks

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24