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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myd88em1.1Rsky
endonuclease-mediated mutation 1.1, Klaus Rajewsky
MGI:7281146
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7281484
cn2
 		Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7281485
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88em1.1Rsky 		involves: C57BL/6NTac MGI:7281480
cn4
 		Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88+ 		involves: C57BL/6NTac MGI:7281482


Genotype
MGI:7281484
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:308792 )
N
• normal Ig class switching in germinal center B cells after immunization with hapten-carrier conjugate NP-CGG
• normal rise and fall of hapten-specific IgG levels after immunization with hapten-carrier conjugate NP-CGG
abnormal somatic hypermutation frequency ( J:308792 )
• increased frequency in IgM+ plasma cells
increased germinal center B cell number ( J:308792 )
• increased frequency and number
increased plasma cell number ( J:308792 )
• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of plasma cells and germinal center B cells
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

immune system
abnormal somatic hypermutation frequency ( J:308792 )
• increased frequency in IgM+ plasma cells
increased germinal center B cell number ( J:308792 )
• increased frequency and number
increased plasma cell number ( J:308792 )
• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of plasma cells and germinal center B cells
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG
• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792




Genotype
MGI:7281485
cn2
Allelic
Composition		 Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre/ERT2)Rsky mutation (1 available); any Cd19 mutation (57 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

immune system
increased plasma cell number ( J:308792 )
• 15x increase in spleen 10 days after tamoxifen tre
• persistently high number of IgM+ plasma cells in spleen and bone marrow for at least 70 weeks after tamoxifen treatment
increased IgM level ( J:308792 )
• high total IgM serum levels for at least 70 weeks after tamoxifen treatment, displaying discrete paraprotein bands in the gamma-globulin zone upon serum protein electrophoresis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
monoclonal gammopathy of uncertain significance DOID:7442 J:308792




Genotype
MGI:7281480
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88em1.1Rsky
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (57 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell proliferation ( J:308792 )
• transient expansion of B cells in absence or presence of added mitogens in vitro

hematopoietic system
increased B cell proliferation ( J:308792 )
• transient expansion of B cells in absence or presence of added mitogens in vitro

immune system
increased B cell proliferation ( J:308792 )
• transient expansion of B cells in absence or presence of added mitogens in vitro




Genotype
MGI:7281482
cn4
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (57 available)
Myd88em1.1Rsky mutation (0 available); any Myd88 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:308792 )
N
• normal B cell development in bone marrow
• normal Ig class switching in B cells in spleen, mesenteric lymph nodes and Peyers patches
enlarged spleen ( J:308792 )
• from age 30 weeks
increased germinal center B cell number ( J:308792 )
• increased frequency and number from age 30 weeks, increasing over time
increased plasma cell number ( J:308792 )
• increased number of IgM+ plasma cells
• increased plasma cell compartment in spleen and bone marrow
• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time
• normal frequency of follicular and marginal zone B cells
increased IgM level ( J:308792 )
• increased serum levels from age 10 weeks, increasing over time

immune system
enlarged spleen ( J:308792 )
• from age 30 weeks
increased germinal center B cell number ( J:308792 )
• increased frequency and number from age 30 weeks, increasing over time
increased plasma cell number ( J:308792 )
• increased number of IgM+ plasma cells
• increased plasma cell compartment in spleen and bone marrow
• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks
abnormal splenic cell ratio ( J:308792 )
• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time
• normal frequency of follicular and marginal zone B cells
increased IgM level ( J:308792 )
• increased serum levels from age 10 weeks, increasing over time

growth/size/body
enlarged spleen ( J:308792 )
• from age 30 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory