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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adarem1Stsn
endonuclease-mediated mutation 1, Daniel B Stetson
MGI:7281512
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adarem1Stsn/Adarem1Stsn involves: C57BL/6J MGI:7281831
ht2
Adarem1Stsn/Adartm1Olds involves: 129S/SvEv * C57BL/6J MGI:7281832
cn3
Adarem1Stsn/Adartm1.1Phs
Ifih1tm1.1Cln/Ifih1tm1.1Cln
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:7281845
cn4
Adarem1Stsn/Adartm1.1Phs
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:7281842
cx5
Adarem1Stsn/Adartm1Olds
Rnaseltm1Slvm/Rnaseltm1Slvm
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:7281851
cx6
Adarem1Stsn/Adartm1Olds
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J MGI:7281848
cx7
Adarem1Stsn/Adartm1Olds
Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J MGI:7281849
cx8
Adarem1Stsn/Adartm1Olds
Ifih1tm1.1Cln/Ifih1tm1.1Cln
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J MGI:7281844
cx9
Adarem1Stsn/Adartm1Olds
Dhx58tm1Itl/Dhx58tm1Itl
involves: 129S/SvEv * C57BL/6J * C57BL/6NTac MGI:7281847


Genotype
MGI:7281831
hm1
Allelic
Composition
Adarem1Stsn/Adarem1Stsn
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• mice born at expected Mendelian ratios

growth/size/body
N
• normal weight, weight gain and growth

mortality/aging
N
• normal survival




Genotype
MGI:7281832
ht2
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at weaning

hematopoietic system
• lymphoid depletion

homeostasis/metabolism
• increased expression of interferon-stimulated genes in cerebellum, kidney and liver
• increased expression of integrated stress response (ISR) genes in kidney and liver
• normal expression of integrated stress response (ISR) genes in cerebellum

immune system
• lymphoid depletion

liver/biliary system
• extensive microvesicular cytoplasmic vacuolation

mortality/aging
• no survival beyond ~130 days

renal/urinary system
• significant immunoglobulin G (IgG) deposition
• increasing with age




Genotype
MGI:7281845
cn3
Allelic
Composition
Adarem1Stsn/Adartm1.1Phs
Ifih1tm1.1Cln/Ifih1tm1.1Cln
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1.1Phs mutation (2 available); any Adar mutation (72 available)
Ifih1tm1.1Cln mutation (2 available); any Ifih1 mutation (45 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• normal weight, weight gain and growth

mortality/aging
N
• normal survival




Genotype
MGI:7281842
cn4
Allelic
Composition
Adarem1Stsn/Adartm1.1Phs
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1.1Phs mutation (2 available); any Adar mutation (72 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at weaning

mortality/aging
• no survival beyond ~84 days




Genotype
MGI:7281851
cx5
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Rnaseltm1Slvm mutation (0 available); any Rnasel mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• normal weight, weight gain and growth

mortality/aging
N
• normal survival




Genotype
MGI:7281848
cx6
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• normal weight, weight gain and growth

homeostasis/metabolism
N
• normal expression of interferon-stimulated genes in cerebellum, kidney and liver
• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging
N
• normal survival




Genotype
MGI:7281849
cx7
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Eif2ak2tm1Jcbe mutation (2 available); any Eif2ak2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• normal expression of interferon-stimulated genes in kidney
• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver
• increased expression of interferon-stimulated genes in cerebellum and liver
• normal expression of interferon-stimulated genes in kidney

growth/size/body
• normal weight, weight gain and growth

mortality/aging
• normal survival




Genotype
MGI:7281844
cx8
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Ifih1tm1.1Cln/Ifih1tm1.1Cln
Genetic
Background
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Ifih1tm1.1Cln mutation (2 available); any Ifih1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• normal weight, weight gain and growth

homeostasis/metabolism
N
• normal expression of interferon-stimulated genes in cerebellum, kidney and liver
• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging
N
• normal survival




Genotype
MGI:7281847
cx9
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Dhx58tm1Itl/Dhx58tm1Itl
Genetic
Background
involves: 129S/SvEv * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (72 available)
Adartm1Olds mutation (0 available); any Adar mutation (72 available)
Dhx58tm1Itl mutation (0 available); any Dhx58 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• normal weight, weight gain and growth

homeostasis/metabolism
N
• normal expression of interferon-stimulated genes in cerebellum, kidney and liver
• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging
N
• normal survival





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory