All Phenotypes Adar<em1Stsn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adar^em1Stsn
endonuclease-mediated mutation 1, Daniel B Stetson
MGI:7281512

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adar^em1Stsn/Adar^em1Stsn	involves: C57BL/6J	MGI:7281831
ht2	Adar^em1Stsn/Adar^tm1Olds	involves: 129S/SvEv * C57BL/6J	MGI:7281832
cn3	Adar^em1Stsn/Adar^tm1.1Phs Ifih1^tm1.1Cln/Ifih1^tm1.1Cln Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:7281845
cn4	Adar^em1Stsn/Adar^tm1.1Phs Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:7281842
cx5	Adar^em1Stsn/Adar^tm1Olds Rnasel^tm1Slvm/Rnasel^tm1Slvm	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:7281851
cx6	Adar^em1Stsn/Adar^tm1Olds Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	MGI:7281848
cx7	Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:7281849
cx8	Adar^em1Stsn/Adar^tm1Olds Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J	MGI:7281844
cx9	Adar^em1Stsn/Adar^tm1Olds Dhx58^tm1Itl/Dhx58^tm1Itl	involves: 129S/SvEv * C57BL/6J * C57BL/6NTac	MGI:7281847

Allelic Composition	Adar^em1Stsn/Adar^em1Stsn
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:308678 )

N	• mice born at expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (72 available)
Adar^tm1Olds mutation (0 available); any Adar mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:308678 )

• at weaning

hematopoietic system

abnormal spleen morphology ( J:308678 )

• lymphoid depletion

homeostasis/metabolism

abnormal homeostasis ( J:308678 )

• increased expression of interferon-stimulated genes in cerebellum, kidney and liver

• increased expression of integrated stress response (ISR) genes in kidney and liver

• normal expression of integrated stress response (ISR) genes in cerebellum

increased circulating alkaline phosphatase level ( J:308678 )

decreased circulating serum albumin level ( J:308678 )

immune system

abnormal spleen morphology ( J:308678 )

• lymphoid depletion

liver/biliary system

abnormal liver morphology ( J:308678 )

• extensive microvesicular cytoplasmic vacuolation

mortality/aging

lethality, complete penetrance ( J:308678 )

• no survival beyond ~130 days

renal/urinary system

abnormal renal glomerulus morphology ( J:308678 )

• significant immunoglobulin G (IgG) deposition

expanded mesangial matrix ( J:308678 )

• increasing with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Aicardi-Goutieres syndrome		DOID:0050629	OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750	J:308678

Allelic Composition	Adar^em1Stsn/Adar^tm1.1Phs Ifih1^tm1.1Cln/Ifih1^tm1.1Cln Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (72 available)
Adar^tm1.1Phs mutation (2 available); any Adar mutation (72 available)
Ifih1^tm1.1Cln mutation (2 available); any Ifih1 mutation (45 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1.1Phs Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (72 available)
Adar^tm1.1Phs mutation (2 available); any Adar mutation (72 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:308678 )

• at weaning

mortality/aging

lethality, complete penetrance ( J:308678 )

• no survival beyond ~84 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Aicardi-Goutieres syndrome		DOID:0050629	OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750	J:308678

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Rnasel^tm1Slvm/Rnasel^tm1Slvm
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Ifnar1^tm1Agt/Ifnar1^tm1Agt
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

• normal expression of interferon-stimulated genes in kidney

• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

abnormal homeostasis ( J:308678 )

• increased expression of interferon-stimulated genes in cerebellum and liver

• normal expression of interferon-stimulated genes in kidney

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Dhx58^tm1Itl/Dhx58^tm1Itl
Genetic Background	involves: 129S/SvEv * C57BL/6J * C57BL/6NTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24