Phenotypes associated with this allele

• Allele Symbol: Npsr1^em1Yfu
• Allele Name: endonuclease-mediated mutation 1, Ying-Hui Fu
• Allele ID: MGI:7284431
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Npsr1^em1Yfu/Npsr1^+	C57BL/6J-Npsr1^em1Yfu	MGI:7284791

Genotype
MGI:7284791

ht1

• Allelic Composition: Npsr1^em1Yfu/Npsr1⁺
• Genetic Background: C57BL/6J-Npsr1^em1Yfu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced contextual conditioning behavior ( J:325012 )

• no reduction in freezing time after 6 h. sleep deprivation

• normal freezing behavior without sleep deprivation

abnormal locomotor circadian rhythm ( J:325012 )

• increased mobile time and greater distance traveled during both light and dark phases

• reduced number of mobile episodes during both light and dark phases

abnormal circadian sleep/wake cycle ( J:325012 )

• 71 min. shorter total sleep time and sleep duration

• sustain higher sleep pressure

• reduced sleep time and increased sleep pressure in dark period after 6 h. sleep deprivation

• increased EEG delta range (1 to 4 Hz) power in dark phase after 6 h. sleep deprivation

• normal sleep gain after 6 h. sleep deprivation

abnormal non-rapid eye movement sleep pattern ( J:325012 )

• shorter duration during both light and dark phases but most pronounced in latter

• increased EEG delta range (1 to 4 Hz) power during NREM sleep in dark phase

abnormal paradoxical sleep pattern ( J:325012 )

• shorter duration of REM sleep during dark pha

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sleep disorder		DOID:535		J:325012