Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slfn14em1Nvm endonuclease-mediated mutation 1, Neil V Morgan MGI:7286186 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice survive to weaning
• if pups survive beyond E14.5, they die shortly after birth
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• E12.5 and E14.5 embryos are much more pale, with less vascular definition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia
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• increase in spleen weight and size
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• mice show differences in erythroid progenitors in the spleen and bone marrow, indicating upregulation of erythropoiesis
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• spleen is a secondary site for erythropoiesis; intermediate progenitors (EryBs) differentiate into mature erythrocytes (EryCs), which are highly populated within the spleen, suggesting erythroid maturation from the intermediate progenitor within the spleen
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• increase in the proportion of proerythroblasts in the spleen
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• mice exhibit microcytic erythrocytosis, an increase in erythrocyte count accompanied by a reduction in size
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• lower hemoglobin levels
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• mice exhibit microcytic erythrocytosis, an increase in erythrocyte count accompanied by a reduction in size
• irregularly shaped smaller erythrocytes (poikilocytes and microcytes)
• however, no difference in leukocyte counts
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• mice show a 15% increase in the proportion of CD41+ SYTO13+ cells, indicating an increase in the proportion of immature platelets
• however, mice exhibit normal platelet function in response to major agonists thrombin, collagen, and collagen-related peptide and normal platelet adhesion and spreading
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• increase in platelet size
• however, no difference in platelet count is seen
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• almost 3-fold increase in megakaryocyte-erythroid progenitors
• however, megakaryocyte counts in spleen are normal and the proportion of megakaryocytes is unchanged
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• following laser injury, mice form thrombi at a similar rate as controls, although they are smaller, with fewer platelets recruited, and embolize more quickly than in controls
• FeCl3 injury to the carotid artery results in occlusive thrombus formation as in wild-type mice, however mutants form thrombi at a slightly slower rate and have a tendency for reduced stability but not significantly
• however, mice exhibit normal bleeding times with tail tip excision and normal clot retraction
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• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia
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• increase in spleen weight and size
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• splenomegaly is due to extramedullary erythropoiesis, the accumulation of mature erythrocytes, and hemolytic anemia
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• increase in spleen weight and size
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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