Analysis Tools
nervous system
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• in male and female mice at 13 months of age
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• in male and female mice at 6 weeks and 13 months of age
• however, brain weight at E16.5 is normal
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• increased thickness of cortical layer IV/V, layer VI, and entire cortex
• however, neuronal density is normal
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astrocytosis
(
J:325096
)
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• increased soma size at DIV4
• however, mice exhibit normal dendritic length and soma-proximal branching
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• reduced single-axon specification
• however, treatment with rapamycin restores axon specification
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behavior/neurological
| N |
• mice exhibit normal gross motor skills and coordination and social and behavioral assay performance
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• reduced hindlimb strength at 6 weeks, 3 months, and 6 months that cannot be restored with rapamycin treatment
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• abnormal stance and gait
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• with increased stride offset and stance length
• however, sway length is normal
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hypoactivity
(
J:325096
)
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• reduces distance traveled in an open field test at 6 months of age due to reduced walking speed
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growth/size/body
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• at 6 months of age
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muscle
homeostasis/metabolism
| N |
• mice exhibit normal fasting insulin and glucose levels and glucose and insulin tolerance
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