Phenotypes associated with this allele

• Allele Symbol: Pvrig^tm1.2Sgng
• Allele Name: targeted mutation 1.1, Sudipto Ganguly
• Allele ID: MGI:7287678
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pvrig^tm1.2Sgng/Pvrig^tm1.2Sgng	B6(Cg)-Pvrig^tm1.1Sgng	MGI:7287680

Genotype
MGI:7287680

hm1

• Allelic Composition: Pvrig^tm1.2Sgng/Pvrig^tm1.2Sgng
• Genetic Background: B6(Cg)-Pvrig^tm1.1Sgng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell physiology ( J:324171 )

• splenocytes activated with immobilized anti-CD3 and soluble PVRL2-Fc fail to exhibit an inhibition in T cell proliferation unlike wild-type cells

• T cells become effectors more rapidly than wild-type cells in vitro

• mice mount stronger antigen-specific T effector responses against LmOva compared with wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:324171 )

• CD8+ effector cells inhibit growth of implanted tumor cells more than wild-type effector cells

• PD-L1 blockage increased reduction in tumor growth of implanted tumors

immune system

abnormal T cell physiology ( J:324171 )

• splenocytes activated with immobilized anti-CD3 and soluble PVRL2-Fc fail to exhibit an inhibition in T cell proliferation unlike wild-type cells

• T cells become effectors more rapidly than wild-type cells in vitro

• mice mount stronger antigen-specific T effector responses against LmOva compared with wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:324171 )

• CD8+ effector cells inhibit growth of implanted tumor cells more than wild-type effector cells

• PD-L1 blockage increased reduction in tumor growth of implanted tumors