Phenotypes associated with this allele

• Allele Symbol: Svbp^em1Mjom
• Allele Name: endonuclease-mediated mutation 1, Marie-Jo Moutin
• Allele ID: MGI:7287850
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Svbp^em1Mjom/Svbp^em1Mjom	C57BL/6-Svbp^em1Mjom	MGI:7293339
cx2	Matcap1^em1Nki/Matcap1^em1Nki Svbp^em1Mjom/Svbp^em1Mjom	involves: C57BL/6	MGI:7293341

Genotype
MGI:7293339

hm1

• Allelic Composition: Svbp^em1Mjom/Svbp^em1Mjom
• Genetic Background: C57BL/6-Svbp^em1Mjom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:325393 , J:325763 )

• decreased volume (J:325393)

• decreased volume (J:325763)

decreased corpus callosum size ( J:325763 )

• decreased volume

decreased anterior commissure size ( J:325763 )

abnormal brainstem morphology ( J:325763 )

• decreased volume

decreased striatum size ( J:325763 )

• decreased volume

abnormal hypothalamus morphology ( J:325763 )

• decreased volume

small thalamus ( J:325763 )

• decreased volume

decreased hippocampal fimbria size ( J:325763 )

• decreased volume

abnormal cerebral cortex morphology ( J:325763 )

• decreased volume

small olfactory bulb ( J:325393 )

• decreased volume

small cerebellum ( J:325393 )

• decreased volume

abnormal neurite morphology ( J:325763 )

• at 2 days in vitro (DIV), cultured neurons exhibit increased number of primary neurites and extra branches with reduced axon length compared with wild-type cells

abnormal axon morphology ( J:325763 )

• decreased length at 2 DIV

abnormal dendrite morphology ( J:325763 )

• increased dendritic branching at 17 DIV

behavior/neurological

behavior/neurological phenotype ( J:325763 )

N • mice exhibit normal performance in a Y-maze, spatial learning and memory

decreased exploration in new environment ( J:325763 )

• in the Hamlet test, mice spend more time in the Hide house compared with wild-type mice

decreased anxiety-related response ( J:325763 )

• mice exhibit reduced marble burying compared with wild-type mice

• however, mice exhibit normal performance in an elevated plus maze

hyperactivity ( J:325763 )

decreased social investigation ( J:325763 )

♂ • by male mice in an intruder test

growth/size/body

microcephaly ( J:325763 )

• more severely affecting white matter

Genotype
MGI:7293341

cx2

• Allelic Composition: Matcap1^em1Nki/Matcap1^em1Nki; Svbp^em1Mjom/Svbp^em1Mjom
• Genetic Background: involves: C57BL/6

behavior/neurological

abnormal nest building behavior ( J:325393 )

• mice fail to build nests unlike wild-type mice

nervous system

decreased neuronal precursor proliferation ( J:325393 )

• at E14.5 in the ventricular and subventricular zone

decreased brain size ( J:325393 )

• more severe than in single homozygotes

small olfactory bulb ( J:325393 )

• more severe than in single homozygotes

small cerebellum ( J:325393 )

• more severe than in single homozygotes

cellular

decreased neuronal precursor proliferation ( J:325393 )

• at E14.5 in the ventricular and subventricular zone