All Phenotypes Folh1<em2Smoc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Folh1^em2Smoc
endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI:7289725

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Folh1^em2Smoc/Folh1^em2Smoc	involves: C57BL/6J	MGI:7662578
cx2	Folh1^em2Smoc/Folh1^em2Smoc Naalad2^em1Jzhan/Naalad2^em1Jzhan	involves: C57BL/6 * C57BL/6J	MGI:7662577

Allelic Composition	Folh1^em2Smoc/Folh1^em2Smoc
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1^em2Smoc mutation (0 available); any Folh1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased glutamic acid level ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

decreased susceptibility to injury ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

• decrease in neuronal damage and apoptosis following TBI

• recovery of neurons following TBI is enhanced compared to similarly treated wild-type controls

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological

enhanced spatial learning ( J:344894 )

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

Allelic Composition	Folh1^em2Smoc/Folh1^em2Smoc Naalad2^em1Jzhan/Naalad2^em1Jzhan
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1^em2Smoc mutation (0 available); any Folh1 mutation (50 available)
Naalad2^em1Jzhan mutation (0 available); any Naalad2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased glutamic acid level ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

decreased susceptibility to injury ( J:344894 )

• rise in levels of glutamate following traumatic brain injury (TBI) is reduced compared to similarly treated wild-type controls

• decrease in neuronal damage and apoptosis following TBI

• recovery of neurons following TBI is enhanced compared to wild-type controls

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological

enhanced spatial learning ( J:344894 )

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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