All Phenotypes Folh1<em2Smoc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Folh1^em2Smoc
endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI:7289725

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Folh1^em2Smoc/Folh1^em2Smoc	involves: C57BL/6J	MGI:7662578
cx2	Folh1^em2Smoc/Folh1^em2Smoc Naalad2^em1Jzhan/Naalad2^em1Jzhan	involves: C57BL/6 * C57BL/6J	MGI:7662577

Allelic Composition	Folh1^em2Smoc/Folh1^em2Smoc
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1^em2Smoc mutation (0 available); any Folh1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased glutamic acid level ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

decreased susceptibility to injury ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

• decrease in neuronal damage and apoptosis following TBI

• recovery of neurons following TBI is enhanced compared to similarly treated wild-type controls

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological

enhanced spatial learning ( J:344894 )

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

Allelic Composition	Folh1^em2Smoc/Folh1^em2Smoc Naalad2^em1Jzhan/Naalad2^em1Jzhan
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1^em2Smoc mutation (0 available); any Folh1 mutation (50 available)
Naalad2^em1Jzhan mutation (0 available); any Naalad2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased glutamic acid level ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

decreased susceptibility to injury ( J:344894 )

• rise in levels of glutamate following traumatic brain injury (TBI) is reduced compared to similarly treated wild-type controls

• decrease in neuronal damage and apoptosis following TBI

• recovery of neurons following TBI is enhanced compared to wild-type controls

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological

enhanced spatial learning ( J:344894 )

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24