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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Folh1em2Smoc
endonuclease-mediated mutation 2, Shanghai Model Organisms Center
MGI:7289725
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Folh1em2Smoc/Folh1em2Smoc involves: C57BL/6J MGI:7662578
cx2
Folh1em2Smoc/Folh1em2Smoc
Naalad2em1Jzhan/Naalad2em1Jzhan
involves: C57BL/6 * C57BL/6J MGI:7662577


Genotype
MGI:7662578
hm1
Allelic
Composition
Folh1em2Smoc/Folh1em2Smoc
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1em2Smoc mutation (0 available); any Folh1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls
• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls
• decrease in neuronal damage and apoptosis following TBI
• recovery of neurons following TBI is enhanced compared to similarly treated wild-type controls
• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological
• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls




Genotype
MGI:7662577
cx2
Allelic
Composition
Folh1em2Smoc/Folh1em2Smoc
Naalad2em1Jzhan/Naalad2em1Jzhan
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Folh1em2Smoc mutation (0 available); any Folh1 mutation (50 available)
Naalad2em1Jzhan mutation (0 available); any Naalad2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls
• rise in levels of glutamate following traumatic brain injury (TBI) is reduced compared to similarly treated wild-type controls
• decrease in neuronal damage and apoptosis following TBI
• recovery of neurons following TBI is enhanced compared to wild-type controls
• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological
• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory