Phenotypes associated with this allele

• Allele Symbol: Atp23^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen
• Allele ID: MGI:7294249
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp23^em1Cya/Atp23^em1Cya	involves: C57BL/6N	MGI:7294251

Genotype
MGI:7294251

hm1

• Allelic Composition: Atp23^em1Cya/Atp23^em1Cya
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:325725 )

• pups are present in expected numbers at E15.5 and E18.5, but all die between E18.5 and 6 hours after birth

respiratory system

abnormal lung development ( J:325725 )

• at the late canalicular stage (E17.5) lungs show a dense appearance and little saccular expansion

impaired lung alveolus development ( J:325725 )

• at E18.5 lungs display decreased expression of type I and type II alveolar epithelial cell differentiation markers

thick lung-associated mesenchyme ( J:325725 )

• increased thickness of the mesenchymal septa at E18.5

small lung ( J:325725 )

• at E18.5

abnormal pulmonary alveolus morphology ( J:325725 )

• reduced amounts of alveoli at E18.5

decreased alveolar lamellar body number ( J:325725 )

• at E18.5

atelectasis ( J:325725 )

• at E18.5

• reduced interalveolar space and decrease in the number of distal alveoli

• no tracheal dysfunction is seen

pale lung ( J:325725 )

• at E18.5

abnormal surfactant physiology ( J:325725 )

• decrease in the amount of surfactant-associated proteins in the lungs at E18.5

growth/size/body

decreased fetal size ( J:325725 )

• at E15.5 and E18.5

integument

pallor ( J:325725 )

• appear a little whiter than litter-mates at E15.5 and E18.5