Phenotypes associated with this allele

• Allele Symbol: Dgkh^tm1Skne
• Allele Name: targeted mutation 1, Fumio Sakane
• Allele ID: MGI:7294346
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dgkh^tm1Skne/Dgkh^tm1Skne	B6.Cg-Dgkh^tm1Skne	MGI:7294349

Genotype
MGI:7294349

hm1

• Allelic Composition: Dgkh^tm1Skne/Dgkh^tm1Skne
• Genetic Background: B6.Cg-Dgkh^tm1Skne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:234190 )

• moderately impaired learning and memory performance in the Barnes maze test

abnormal spatial working memory ( J:234190 )

• moderately impaired learning and memory performance in the Barnes maze test

increased coping response ( J:234190 )

• decreased immobility in the tail suspension test

decreased anxiety-related response ( J:234190 )

• increased time spent in the center area in an open field test

• increased time in open arms of an elevated plus maze

hyperactivity ( J:234190 )

• indicated by quickly changing their behavior

• however, treatment with LiCl reverses manic-like behavior