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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn20em1Mmsk
endonuclease-mediated mutation 1, Masakazu Miyajima
MGI:7294472
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptpn20em1Mmsk/Ptpn20em1Mmsk C57BL/6J-Ptpn20em1Mmsk MGI:7294474


Genotype
MGI:7294474
hm1
Allelic
Composition		 Ptpn20em1Mmsk/Ptpn20em1Mmsk
Genetic
Background		 C57BL/6J-Ptpn20em1Mmsk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn20em1Mmsk mutation (0 available); any Ptpn20 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:326016 )
N
• mice exhibit normal choroid plexus epithelial cells
non-obstructive hydrocephaly ( J:326016 )
• in 16 of 29 mice
enlarged brain ventricles ( J:326016 )
• very mild ventriculomegaly in some mice
abnormal cerebrospinal fluid physiology ( J:326016 )
• disrupted cerebrospinal fluid drainage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory