About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc65em11Gpt
endonuclease-mediated mutation 11, GemPharmatech Co., Ltd
MGI:7296395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc65em11Gpt/Ccdc65em11Gpt C57BL/6J-Ccdc65em11Gpt MGI:7606224
ht2
 		Ccdc65em11Gpt/Ccdc65+ C57BL/6J-Ccdc65em11Gpt MGI:7606229


Genotype
MGI:7606224
hm1
Allelic
Composition		 Ccdc65em11Gpt/Ccdc65em11Gpt
Genetic
Background		 C57BL/6J-Ccdc65em11Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc65em11Gpt mutation (0 available); any Ccdc65 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:327251 )
• all mice die within 3 weeks after birth, possibly due to hydrocephalus
prenatal lethality, incomplete penetrance ( J:327251 )
• birth rate is lower than that expected from Mendelian ratios

growth/size/body
megacephaly ( J:327251 )
• mice exhibit a larger head size than wild-type or heterozygous mice
decreased body size ( J:327251 )
postnatal growth retardation ( J:327251 )
• mice develop slowly relative to wild-type or heterozygous mice

nervous system
abnormal brain morphology ( J:327251 )
• the craniocerebral diameter ratio is significantly lower than that in wild-type or heterozygous mice, and brain tissue appears sunken rather than full
enlarged lateral ventricles ( J:327251 )
• mice show significantly larger lateral ventricles than wild-type or heterozygous mice
abnormal cerebrospinal fluid flow ( J:327251 )
• mice exhibit disordered circulation of cerebrospinal fluid




Genotype
MGI:7606229
ht2
Allelic
Composition		 Ccdc65em11Gpt/Ccdc65+
Genetic
Background		 C57BL/6J-Ccdc65em11Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc65em11Gpt mutation (0 available); any Ccdc65 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:327251 )
• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:327251 )
• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory