All Phenotypes Csta1<em1Gpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Csta1^em1Gpt
endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI:7297511

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Csta1^em1Gpt/Csta1^em1Gpt	C57BL/6JGpt-Csta1^em1Gpt	MGI:7550398

Allelic Composition	Csta1^em1Gpt/Csta1^em1Gpt
Genetic Background	C57BL/6JGpt-Csta1^em1Gpt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csta1^em1Gpt mutation (0 available); any Csta1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:340112 )

• in mice treated with a cre-expressing adenovirus

• however, osteopenia is reversed by Csta supplementation

decreased compact bone mass ( J:340112 )

• in mice treated with a cre-expressing adenovirus

decreased osteoblast cell number ( J:340112 )

• in mice treated with a cre-expressing adenovirus

decreased trabecular bone mass ( J:340112 )

• in mice treated with a cre-expressing adenovirus

integument

decreased keratinocyte proliferation ( J:340112 )

• in mice treated with a cre-expressing adenovirus

abnormal keratinocyte morphology ( J:340112 )

• decreased keratinocyte number in mice treated with a cre-expressing adenovirus

thin epidermis ( J:340112 )

• in mice treated with a cre-expressing adenovirus

cellular

decreased keratinocyte proliferation ( J:340112 )

• in mice treated with a cre-expressing adenovirus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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