All Phenotypes Diras2<em1Gpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Diras2^em1Gpt
endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI:7298011

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJae * C57BL/6	MGI:7738284
cn2	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * C57BL/6J * C57BL/6JGpt	MGI:7738283

Allelic Composition	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diras2^em1Gpt mutation (0 available); any Diras2 mutation (20 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

neoplasm