Phenotypes associated with this allele

• Allele Symbol: Igs2^{em53(Myh6-cre/ERT2)Gpt}
• Allele Name: endonuclease-mediated mutation 53, GemPharmatech Co., Ltd
• Allele ID: MGI:7300666
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igs2^em53(Myh6-cre/ERT2)Gpt/Igs2^+ Stx17^em1Gpt/Stx17^em1Gpt	involves: C57BL/6JGpt	MGI:7608030

Genotype
MGI:7608030

cn1

• Allelic Composition: Igs2^{em53(Myh6-cre/ERT2)Gpt}/Igs2⁺; Stx17^em1Gpt/Stx17^em1Gpt
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:345305 )

• high-fat diet induced cardiac fibrosis is alleviated in tamoxifen treated mice

• no abnormalities in cardiac morphology in tamoxifen treated mice on a normal diet

abnormal myocardial fiber morphology ( J:345305 )

• high-fat diet induced increase in cardiomyocyte cross-sectional are is alleviated in tamoxifen treated mice

abnormal cardiovascular system physiology ( J:345305 )

• alleviation of high-fat diet induced cardiac oxidative stress and lipid peroxidation in tamoxifen treated mice

abnormal cardiac muscle contractility ( J:345305 )

• reduction in the high-fat diet induced decreases in ejection fraction and fractional shortening in tamoxifen treated mice

growth/size/body

growth/size/body region phenotype ( J:345305 )

N • no difference in body weight in tamoxifen treated mice on a high fat diet compared to diet matched controls

muscle

abnormal myocardial fiber morphology ( J:345305 )

• high-fat diet induced increase in cardiomyocyte cross-sectional are is alleviated in tamoxifen treated mice

abnormal cardiac muscle contractility ( J:345305 )

• reduction in the high-fat diet induced decreases in ejection fraction and fractional shortening in tamoxifen treated mice