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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krasem1Gpt
endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI:7301371
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		2610035D17Rikem1Zhgn/2610035D17Rikem1Zhgn
Krasem1Gpt/Kras+
Tg(Pdx1-cre)89.1Dam/0 		involves: C57BL/6JGpt * CBA MGI:7541339
cn2
 		2610035D17Rikem2Zhgn/2610035D17Rikem2Zhgn
Krasem1Gpt/Kras+
Tg(Pdx1-cre)89.1Dam/0
Trp53em3Gpt/Trp53+ 		involves: C57BL/6JGpt * CBA MGI:7541340


Genotype
MGI:7541339
cn1
Allelic
Composition		 2610035D17Rikem1Zhgn/2610035D17Rikem1Zhgn
Krasem1Gpt/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background		 involves: C57BL/6JGpt * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610035D17Rikem1Zhgn mutation (0 available); any 2610035D17Rik mutation (2 available)
Krasem1Gpt mutation (0 available); any Kras mutation (84 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased gland tumor incidence ( J:339253 )
• reduced pancreatic intraepithelial neoplasia incidence at both 6 and 9 months of age compared with Krasem1Gpt/ Kras+ Tg(Pdx1-cre)89.1Dam mice

endocrine/exocrine glands
decreased gland tumor incidence ( J:339253 )
• reduced pancreatic intraepithelial neoplasia incidence at both 6 and 9 months of age compared with Krasem1Gpt/ Kras+ Tg(Pdx1-cre)89.1Dam mice




Genotype
MGI:7541340
cn2
Allelic
Composition		 2610035D17Rikem2Zhgn/2610035D17Rikem2Zhgn
Krasem1Gpt/Kras+
Tg(Pdx1-cre)89.1Dam/0
Trp53em3Gpt/Trp53+
Genetic
Background		 involves: C57BL/6JGpt * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610035D17Rikem2Zhgn mutation (0 available); any 2610035D17Rik mutation (2 available)
Krasem1Gpt mutation (0 available); any Kras mutation (84 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
Trp53em3Gpt mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased gland tumor incidence ( J:339253 )
• reduced pancreatic intraepithelial neoplasia incidence and tumor size compared with Krasem1Gpt/ Kras+ Tg(Pdx1-cre)89.1Dam mice

endocrine/exocrine glands
decreased gland tumor incidence ( J:339253 )
• reduced pancreatic intraepithelial neoplasia incidence and tumor size compared with Krasem1Gpt/ Kras+ Tg(Pdx1-cre)89.1Dam mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory