Analysis Tools
immune system
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• mice infected with HSV-1 or VSV show higher serum production of interferon-beta1
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• mice are more susceptible to LPS stimulation, with reduced survival 12-24 hours after LPS injection compared to wild-type mice
• mice challenged with LPS show increased expression of Ifnb1 in the blood, but no differences in Tnf or Il6 expression
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• mice exhibit enhanced antiviral innate immunity, as evidenced by higher cytokine expression or serum production of Ifnb1 and IFN-stimulated genes Ccl5 and Mx1 when infected with HSV-1 or VSV
• induction of Ifnb1, Ccl15, and Mx1, but not Il1b and Tnf in isolated peritoneal macrophages is much greater than in wild-type mice after VSV-GFP infection
• HSV-1- or sendai virus (SeV)-infected bone marrow-derived macrophages (BMDM) show increased expression of viral infection-responsive genes
• however, no difference in the expression of NF-kappaB responsible genes, such as Tnf, Il6, and Il1b is seen
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• mice are less susceptible to herpes simplex type 1 (HSV-1, F strain)
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• mice are less susceptible to vesicular stomatitis virus (VSV; Indiana strain)
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homeostasis/metabolism
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• mice infected with HSV-1 or VSV show higher serum production of interferon-beta1
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