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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem11em4Gpt
endonuclease-mediated mutation 4, GemPharmatech Co., Ltd
MGI:7307591
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem11em4Gpt/Tmem11em4Gpt C57BL/6JGpt-Tmem11em4Gpt MGI:7596042


Genotype
MGI:7596042
hm1
Allelic
Composition		 Tmem11em4Gpt/Tmem11em4Gpt
Genetic
Background		 C57BL/6JGpt-Tmem11em4Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem11em4Gpt mutation (0 available); any Tmem11 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber number ( J:345326 )
• the number of cardiomyocytes is increased
• however, cardiac tissue morphology, heart-to-body weight ratio, and heart function are normal under physiological conditions and no cardiac hypertrophy is seen
abnormal myocardial fiber physiology ( J:345326 )
• hearts show increased cardiomyocyte proliferation
decreased susceptibility to myocardial ischemic injury ( J:345326 )
• mice subjected to myocardial infraction induced by coronary artery ligation exhibit reduced scar size, improved left ventricle function, and increased cardiomyocyte proliferation, indicating improved myocardial repair and cardiac function after ischemic injury

homeostasis/metabolism
decreased susceptibility to myocardial ischemic injury ( J:345326 )
• mice subjected to myocardial infraction induced by coronary artery ligation exhibit reduced scar size, improved left ventricle function, and increased cardiomyocyte proliferation, indicating improved myocardial repair and cardiac function after ischemic injury

muscle
increased myocardial fiber number ( J:345326 )
• the number of cardiomyocytes is increased
• however, cardiac tissue morphology, heart-to-body weight ratio, and heart function are normal under physiological conditions and no cardiac hypertrophy is seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory