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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ube2cem1Gpt
endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI:7308166
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ube2cem1Gpt/Ube2cem1Gpt C57BL/6J-Ube2cem1Gpt MGI:7710914
cn2
 		Krastm4Tyj/Kras+
Ube2cem1Gpt/Ube2cem1Gpt 		involves: 129S4/SvJae * C57BL/6J MGI:7710915
cn3
 		Deptortm1.2Ysun/Deptortm1.2Ysun
Krastm4Tyj/Kras+
Ube2cem1Gpt/Ube2cem1Gpt 		involves: 129S4/SvJae * C57BL/6J MGI:7710919


Genotype
MGI:7710914
cn1
Allelic
Composition		 Ube2cem1Gpt/Ube2cem1Gpt
Genetic
Background		 C57BL/6J-Ube2cem1Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube2cem1Gpt mutation (0 available); any Ube2c mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:333347 )
• mouse embryonic fibroblasts (MEFs) infected with an adenovirus expressing cre recombinase (Ad-cre) exhibit reduced cell growth

neoplasm
neoplasm ( J:333347 )
N
• mice intratracheally administered Ad-cre exhibit normal lung development without any tumor formation

respiratory system
respiratory system phenotype ( J:333347 )
N
• mice intratracheally administered Ad-cre exhibit normal lung development




Genotype
MGI:7710915
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Ube2cem1Gpt/Ube2cem1Gpt
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ube2cem1Gpt mutation (0 available); any Ube2c mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) show reduced lung tumor burden compared to single mutant Kras homozygous mice

mortality/aging
increased tumor-free survival time ( J:333347 )
• mice intratracheally administered Ad-cre have a median survival time of approximately 150 days and 100% death by 210 days compared to single mutant Kras homozygous mice which have a survival time of approximately 130 days with 100% death by 175 days, indicating increased survival

respiratory system
decreased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) show reduced lung tumor burden compared to single mutant Kras homozygous mice




Genotype
MGI:7710919
cn3
Allelic
Composition		 Deptortm1.2Ysun/Deptortm1.2Ysun
Krastm4Tyj/Kras+
Ube2cem1Gpt/Ube2cem1Gpt
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Deptortm1.2Ysun mutation (0 available); any Deptor mutation (29 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ube2cem1Gpt mutation (0 available); any Ube2c mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) develop lung tumor burden similar to single mutant Kras homozygous mice indicating rescue of the suppression of lung tumorigenesis by Ube2c

respiratory system
increased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) develop lung tumor burden similar to single mutant Kras homozygous mice indicating rescue of the suppression of lung tumorigenesis by Ube2c




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory