Analysis Tools
behavior/neurological
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• 8- to 10-week-old male mice show normal total distance travelled and time spent in the central arena in an open field test; normal latency time in the rotarod test; normal distance covered and time spent in open arms in an elevated plus maze test; and normal sucrose preference over water relative to wild-type controls
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• in a tail suspension test (TST), male mice show a significant reduction in curling time but normal immobility time, suggesting a depressive-like behavior; reduced curling time is also noted in TST after chronic restraint stress
• AAV-mediated overexpression of Vrk2 in the ventral hippocampus results in significantly increased curling time, indicating an antidepressant effect
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nervous system
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• mice show a significant decrease in the density of mature mushroom spines in the ventral hippocampus
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• mice show a significant increase in the density of immature thin spines in the ventral hippocampus
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• ventral hippocampus pyramidal neurons show a significant decrease in mushroom spines and a concomitant increase in thin spines
• however, the density of stubby spines and the density of total dendritic spines remain normal
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• phosphoproteomic analyses showed dysregulated proteins in synapse-related functions and pathways in the ventral hippocampus
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