Phenotypes associated with this allele

• Allele Symbol: 5730403I07Rik^em8Gpt
• Allele Name: endonuclease-mediated mutation 8, GemPharmatech Co., Ltd
• Allele ID: MGI:7309177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	5730403I07Rik^em8Gpt/5730403I07Rik^em8Gpt	involves: C57BL/6JGpt	MGI:7640038

Genotype
MGI:7640038

hm1

• Allelic Composition: 5730403I07Rik^em8Gpt/5730403I07Rik^em8Gpt
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell number ( J:329871 )

• difference in the percentages of CD11b+ Ly6G+ Ly6C+ and CD11b+ Ly6G- LyC+ myeloid-derived suppressor cells subsets

abnormal T cell physiology ( J:329871 )

• CD4+ and CD8+T cells from tumors produce higher levels of IFNG

abnormal regulatory T cell physiology ( J:329871 )

• reduced inhibition of T cell proliferation by myeloid-derived suppressor cells

increased interferon-gamma secretion ( J:329871 )

• CD4+ and CD8+T cells from tumors produce higher levels of IFNG

increased inflammatory response ( J:329871 )

• decrease in tumor size is accompanied by increased infiltration of CD4+ and CD8+ T cells and elevated IFNG levels in tumor tissues

neoplasm

decreased tumor growth/size ( J:329871 )

• tumors formed by injection of OVA-expressing B16 melanoma cells are smaller and lighter compared to tumors from similarly treated wild-type mice

• decrease in size is accompanied by increased infiltration of CD4+ and CD8+ T cells in tumor tissues

hematopoietic system

abnormal T cell number ( J:329871 )

• difference in the percentages of CD11b+ Ly6G+ Ly6C+ and CD11b+ Ly6G- LyC+ myeloid-derived suppressor cells subsets

abnormal T cell physiology ( J:329871 )

• CD4+ and CD8+T cells from tumors produce higher levels of IFNG

abnormal regulatory T cell physiology ( J:329871 )

• reduced inhibition of T cell proliferation by myeloid-derived suppressor cells