Phenotypes associated with this allele

• Allele Symbol: Cldn17^em#Prso
• Allele Name: endonuclease-mediated mutation, Payaningal R Somanath
• Allele ID: MGI:7309978
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn17^em#Prso/Cldn17^em#Prso	C57BL/6-Cldn17^em#Prso	MGI:7309980

Genotype
MGI:7309980

hm1

• Allelic Composition: Cldn17^em#Prso/Cldn17^em#Prso
• Genetic Background: C57BL/6-Cldn17^em#Prso

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:325994 )

• mice appear smaller at P7 and mice show reduced length, however there is a gradual decline in the difference and mice reach parity with wild-type mice at a later stage (8 to 18 weeks) indicating an early delay in growth

• however, no differences in growth hormone production are seen in early-stage pups or adults

behavior/neurological

polydipsia ( J:325994 )

decreased food intake ( J:325994 )

digestive/alimentary system

decreased defecation amount ( J:325994 )

• mice show a reduction in the number of fecal pellets extracted over 24 hours

constipation ( J:325994 )

• mice show a reduction in the number of fecal pellets extracted over 24 hours and fecal pellets show a lower moisture content, signifying constipation

homeostasis/metabolism

increased circulating bicarbonate level ( J:325994 )

decreased circulating sodium level ( J:325994 )

abnormal circulating protein level ( J:325994 )

• total globulin and the albumin to globulin ratio are reduced

• however, total protein and albumin levels are unaltered

increased circulating chloride level ( J:325994 )

abnormal urine homeostasis ( J:325994 )

• rare white blood cells present in wild-type mice, considered normal, are reduced in the urine

• however, all other urine parameters such as the pH, specific gravity, color, bilirubin, bacteria, turbidity, and crystals show no difference from wild-type mice

renal/urinary system

abnormal urine homeostasis ( J:325994 )

• rare white blood cells present in wild-type mice, considered normal, are reduced in the urine

• however, all other urine parameters such as the pH, specific gravity, color, bilirubin, bacteria, turbidity, and crystals show no difference from wild-type mice

abnormal kidney morphology ( J:325994 )

• mice exhibit kidney injury characterized by vacuolar degeneration, mineralization, and increased Bowmans capsule spacing

abnormal renal glomerular capsule morphology ( J:325994 )

• enlarged Bowman's capsule size

increased glomerular capsule space ( J:325994 )

abnormal kidney physiology ( J:325994 )

• kidneys show an increase in ROS levels

cellular

oxidative stress ( J:325994 )

• kidneys show an increase in ROS levels

integument

integument phenotype ( J:325994 )

N • skin sections show normal histology

liver/biliary system

liver/biliary system phenotype ( J:325994 )

N • liver sections show normal histology