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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc3em4Mjn
endonuclease-mediated mutation 4, Maria Jasin
MGI:7310062
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xrcc3em4Mjn/Xrcc3em4Mjn C57BL/6J-Xrcc3em4Mjn MGI:7310096
cx2
 		Trp53tm1Tyj/Trp53+
Xrcc3em4Mjn/Xrcc3em4Mjn 		involves: 129S2/SvPas * C57BL/6J MGI:7310097
cx3
 		Trp53tm1Tyj/Trp53tm1Tyj
Xrcc3em4Mjn/Xrcc3em4Mjn 		involves: 129S2/SvPas * C57BL/6J MGI:7310098


Genotype
MGI:7310096
hm1
Allelic
Composition		 Xrcc3em4Mjn/Xrcc3em4Mjn
Genetic
Background		 C57BL/6J-Xrcc3em4Mjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc3em4Mjn mutation (0 available); any Xrcc3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:320381 )
• no mice are obtained at E13.5 or E12.5 despite being present at E9.5

embryo
abnormal embryo development ( J:320381 )
• at E9.5, 16 of 17 mice exhibit U-shaped lordotic position unlike wild-type mice
embryonic growth arrest ( J:320381 )
• growth arrest at the 6-8 somite stage prior to axial rotation

growth/size/body
decreased embryo size ( J:320381 )
• at E8.25




Genotype
MGI:7310097
cx2
Allelic
Composition		 Trp53tm1Tyj/Trp53+
Xrcc3em4Mjn/Xrcc3em4Mjn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc3em4Mjn mutation (0 available); any Xrcc3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:320381 )
• no mice are present at weaning




Genotype
MGI:7310098
cx3
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Xrcc3em4Mjn/Xrcc3em4Mjn
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc3em4Mjn mutation (0 available); any Xrcc3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:320381 )
• no mice are present at weaning




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory