Phenotypes associated with this allele

• Allele Symbol: Plppr5^em2Gpt
• Allele Name: endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• Allele ID: MGI:7310260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plppr5^em2Gpt/Plppr5^em2Gpt	C57BL/6-Plppr5^em2Gpt	MGI:7310280

Genotype
MGI:7310280

hm1

• Allelic Composition: Plppr5^em2Gpt/Plppr5^em2Gpt
• Genetic Background: C57BL/6-Plppr5^em2Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:324004 )

• following hypoxia-ischemia injury and administration of penicillin, mice treated with vehicle- or melatonin exhibit decreased threshold to seizure compared with control mice

impaired passive avoidance behavior ( J:324004 )

• following hypoxia-ischemia injury, mice treated with vehicle- or melatonin exhibit increased step through test errors and reduced test latency avoidance period compared with similarly treated wild-type mice

decreased thigmotaxis ( J:324004 )

• in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

abnormal response to novel object ( J:324004 )

• reduced novel object discrimination index in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

increased grooming behavior ( J:324004 )

• in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

limb grasping ( J:324004 )

• reduced time in forelimb suspension reflex test for vehicle- or melatonin-treated mice following hypoxia-ischemia injury

abnormal locomotor behavior ( J:324004 )

• following hypoxia-ischemia injury, mice treated with vehicle- or melatonin exhibit decreased counts in a foot fault test compared with wild-type mice

decreased locomotor activity ( J:324004 )

• in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

positive geotaxis ( J:324004 )

• reduced negative geotaxis and cliff avoidance in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

nervous system

increased susceptibility to pharmacologically induced seizures ( J:324004 )

• following hypoxia-ischemia injury and administration of penicillin, mice treated with vehicle- or melatonin exhibit decreased threshold to seizure compared with control mice

increased cerebral infarct size ( J:324004 )

• in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:324004 )

• following hypoxia-ischemia injury, mice exhibit a reduced decreased in cerebral infarct size and asymmetric limb score in a cylinder test; no decrease in surface righting time, surface righting reflex; and no increase in novel object discrimination index or forelimb suspension reflex times compared with wild-type mice

• melatonin-treated mice exhibit reduced weight at P22, P26, P30, P34, and P38 compared with similarly treated wild-type mice

increased cerebral infarct size ( J:324004 )

• in vehicle- or melatonin-treated mice following hypoxia-ischemia injury

growth/size/body

increased body weight ( J:324004 )

• in vehicle-treated mice at P38

decreased susceptibility to weight gain ( J:324004 )

• melatonin-treated mice exhibit reduced weight at P22, P26, P30, P34, and P38 compared with similarly treated wild-type mice