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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nars1em2Rwb
endonuclease-mediated mutation 2, Robert W Burgess
MGI:7310307
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nars1em2Rwb/Nars1em2Rwb C57BL/6J-Nars1em1Rwb/RwbJ MGI:7657440
ht2
 		Nars1em2Rwb/Nars1+ C57BL/6J-Nars1em1Rwb/RwbJ MGI:7657441


Genotype
MGI:7657440
hm1
Allelic
Composition		 Nars1em2Rwb/Nars1em2Rwb
Genetic
Background		 C57BL/6J-Nars1em1Rwb/RwbJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nars1em2Rwb mutation (1 available); any Nars1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:348677 )
• no homozygotes were recovered in 50 pups from heterozygous intercrosses




Genotype
MGI:7657441
ht2
Allelic
Composition		 Nars1em2Rwb/Nars1+
Genetic
Background		 C57BL/6J-Nars1em1Rwb/RwbJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nars1em2Rwb mutation (1 available); any Nars1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:348677 )
N
• Although an orthologous mutation in human causes a dominant peripheral axonal neuropathy, mice heterozygous for this allele on the C57BL/6J background displayed no abnormalities as assessed by peripheral nerve histology, body weight measurement, the inverted wire grid test for grip strength and latency to falling, and nerve conduction velocity measurements of the sciatic nerve. Expression analysis from spinal cord did not find any alteration in the expression of stress response ATF4-target genes.




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory