Phenotypes associated with this allele

• Allele Symbol: Nars1^em2Rwb
• Allele Name: endonuclease-mediated mutation 2, Robert W Burgess
• Allele ID: MGI:7310307
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nars1^em2Rwb/Nars1^em2Rwb	C57BL/6J-Nars1^em1Rwb/RwbJ	MGI:7657440
ht2	Nars1^em2Rwb/Nars1^+	C57BL/6J-Nars1^em1Rwb/RwbJ	MGI:7657441

Genotype
MGI:7657440

hm1

• Allelic Composition: Nars1^em2Rwb/Nars1^em2Rwb
• Genetic Background: C57BL/6J-Nars1^em1Rwb/RwbJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:348677 )

• no homozygotes were recovered in 50 pups from heterozygous intercrosses

Genotype
MGI:7657441

ht2

• Allelic Composition: Nars1^em2Rwb/Nars1⁺
• Genetic Background: C57BL/6J-Nars1^em1Rwb/RwbJ

nervous system

nervous system phenotype ( J:348677 )

N • Although an orthologous mutation in human causes a dominant peripheral axonal neuropathy, mice heterozygous for this allele on the C57BL/6J background displayed no abnormalities as assessed by peripheral nerve histology, body weight measurement, the inverted wire grid test for grip strength and latency to falling, and nerve conduction velocity measurements of the sciatic nerve. Expression analysis from spinal cord did not find any alteration in the expression of stress response ATF4-target genes.