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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir204tm1Liam
targeted mutation 1, Mingyu Liang
MGI:7310317
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir204tm1Liam/Mir204tm1Liam B6.Cg-Mir204tm1Liam MGI:7310330
ht2
 		Mir204tm1Liam/Mir204+ B6.Cg-Mir204tm1Liam MGI:7310342


Genotype
MGI:7310330
hm1
Allelic
Composition		 Mir204tm1Liam/Mir204tm1Liam
Genetic
Background		 B6.Cg-Mir204tm1Liam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir204tm1Liam mutation (0 available); any Mir204 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney interlobular artery morphology ( J:326324 )
• wall/lumen ratio is significantly increased following uninephrectomy, Ang II, and high-salt diet treatment compared to similarly treated controls
albuminuria ( J:326324 )
• increase following uninephrectomy, Ang II, and high-salt diet treatment significantly exacerbated compared to wild-type controls
renal interstitial fibrosis ( J:326324 )
• interstitial fibrosis is increased in mice following uninephrectomy, Ang II, and high-salt diet treatment compared to similarly treated controls
abnormal kidney physiology ( J:326324 )
• increase in mean arterial pressure, systolic blood pressure and diastolic blood pressure induced by uninephrectomy, Ang II, and high-salt diet are significantly attenuated

homeostasis/metabolism
albuminuria ( J:326324 )
• increase following uninephrectomy, Ang II, and high-salt diet treatment significantly exacerbated compared to wild-type controls
increased susceptibility to injury ( J:326324 )
• increased susceptibility to renal injury induced by uninephrectomy, Ang II, and a high-salt (4% NaCl) diet

cardiovascular system
abnormal kidney interlobular artery morphology ( J:326324 )
• wall/lumen ratio is significantly increased following uninephrectomy, Ang II, and high-salt diet treatment compared to similarly treated controls
abnormal renal arterial blood pressure regulation ( J:326324 )
• increase in mean arterial pressure, systolic blood pressure and diastolic blood pressure induced by uninephrectomy, Ang II, and high-salt diet are significantly attenuated




Genotype
MGI:7310342
ht2
Allelic
Composition		 Mir204tm1Liam/Mir204+
Genetic
Background		 B6.Cg-Mir204tm1Liam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir204tm1Liam mutation (0 available); any Mir204 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney interlobular artery morphology ( J:326324 )
• wall/lumen ratio is significantly increased following uninephrectomy, Ang II, and high-salt diet treatment compared to similarly treated controls
albuminuria ( J:326324 )
• increase following uninephrectomy, Ang II, and high-salt diet treatment significantly exacerbated compared to wild-type controls

homeostasis/metabolism
albuminuria ( J:326324 )
• increase following uninephrectomy, Ang II, and high-salt diet treatment significantly exacerbated compared to wild-type controls
increased susceptibility to injury ( J:326324 )
• increased susceptibility to renal injury induced by uninephrectomy, Ang II, and a high-salt (4% NaCl) diet

cardiovascular system
abnormal kidney interlobular artery morphology ( J:326324 )
• wall/lumen ratio is significantly increased following uninephrectomy, Ang II, and high-salt diet treatment compared to similarly treated controls




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory