All Phenotypes Rpap3<tm1c(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rpap3^{tm1c(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:7310425

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:7310428
cn2	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Tg(Vil1-cre/ERT2)23Syr/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6N * DBA/2	MGI:7310427
cn3	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Tg(Vil1-cre/ERT2)23Syr/0	involves: C57BL/6N * DBA/2	MGI:7310426

Allelic Composition	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)
Rpap3^{tm1c(KOMP)Wtsi} mutation (0 available); any Rpap3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:314346 )

• tamoxifen-treated mice are normal and survive for 3 weeks at least

Allelic Composition	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Tg(Vil1-cre/ERT2)23Syr/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpap3^{tm1c(KOMP)Wtsi} mutation (0 available); any Rpap3 mutation (34 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:314346 )

• tamoxifen-treated mice exhibit a delay in epithelium shrinkage compared mice with at least one copy of wild-type Trp53

decreased small intestine length ( J:314346 )

• in tamoxifen-treated mice after 7 days

Allelic Composition	Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: C57BL/6N * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal enterocyte morphology ( J:314346 )

• disorganized with focal crowding in tamoxifen-treated mice after 7 days

abnormal small intestine morphology ( J:314346 )

• in tamoxifen-treated mice after 6 days

abnormal small intestine goblet cell morphology ( J:314346 )

• in tamoxifen-treated mice after 7 days

decreased small intestine length ( J:314346 )

• in tamoxifen-treated mice after 6 days

abnormal intestinal epithelium physiology ( J:314346 )

• tamoxifen-treated mice exhibit reduction in proliferating stem cells and progenitors and increased apoptosis compared with control mice

• however, differentiated Paneth cells are normal

small intestinal inflammation ( J:314346 )

• after 6 days, tamoxifen-treated mice exhibit massive intestinal swelling with a transparent liquid or blood compared with control mice

growth/size/body

weight loss ( J:314346 )

• in tamoxifen-treated mice after 6 days

immune system

small intestinal inflammation ( J:314346 )

• after 6 days, tamoxifen-treated mice exhibit massive intestinal swelling with a transparent liquid or blood compared with control mice

cellular

abnormal small intestine goblet cell morphology ( J:314346 )

• in tamoxifen-treated mice after 7 days

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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