All Phenotypes Adgb<tm1d(KOMP)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adgb^{tm1d(KOMP)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:7311625

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgb^{tm1d(KOMP)Wtsi}/Adgb^{tm1d(KOMP)Wtsi}	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N	MGI:7311626

Allelic Composition	Adgb^{tm1d(KOMP)Wtsi}/Adgb^{tm1d(KOMP)Wtsi}
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgb^{tm1d(KOMP)Wtsi} mutation (0 available); any Adgb mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:326350 )

N	• female mice exhibit normal fertility

abnormal sperm flagellum morphology ( J:326350 )

• bifid tails, loopings of the falgellum

abnormal sperm axoneme morphology ( J:326350 )

• disorganized microtubular structure, lacking of the regular 9+2 structure

short sperm flagellum ( J:326350 )

oligozoospermia ( J:326350 )

• very few spermatozoa and absence of mature sperm without an increase in oxidative stress or apoptotic events

abnormal sperm head morphology ( J:326350 )

abnormal acrosome morphology ( J:326350 )

• immature acrosomal structures

decreased testis weight ( J:326350 )

male infertility ( J:326350 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:326350 )

N	• mice exhibit normal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels

endocrine/exocrine glands

decreased testis weight ( J:326350 )

cellular

abnormal sperm flagellum morphology ( J:326350 )

• bifid tails, loopings of the falgellum

abnormal sperm axoneme morphology ( J:326350 )

• disorganized microtubular structure, lacking of the regular 9+2 structure

short sperm flagellum ( J:326350 )

oligozoospermia ( J:326350 )

• very few spermatozoa and absence of mature sperm without an increase in oxidative stress or apoptotic events

abnormal sperm head morphology ( J:326350 )

abnormal acrosome morphology ( J:326350 )

• immature acrosomal structures

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24