All Phenotypes Adgb<tm1d(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adgb^{tm1d(KOMP)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:7311625

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgb^{tm1d(KOMP)Wtsi}/Adgb^{tm1d(KOMP)Wtsi}	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N	MGI:7311626

Allelic Composition	Adgb^{tm1d(KOMP)Wtsi}/Adgb^{tm1d(KOMP)Wtsi}
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgb^{tm1d(KOMP)Wtsi} mutation (0 available); any Adgb mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:326350 )

N	• female mice exhibit normal fertility

abnormal sperm flagellum morphology ( J:326350 )

• bifid tails, loopings of the falgellum

abnormal sperm axoneme morphology ( J:326350 )

• disorganized microtubular structure, lacking of the regular 9+2 structure

short sperm flagellum ( J:326350 )

oligozoospermia ( J:326350 )

• very few spermatozoa and absence of mature sperm without an increase in oxidative stress or apoptotic events

abnormal sperm head morphology ( J:326350 )

abnormal acrosome morphology ( J:326350 )

• immature acrosomal structures

decreased testis weight ( J:326350 )

male infertility ( J:326350 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:326350 )

N	• mice exhibit normal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels

endocrine/exocrine glands

decreased testis weight ( J:326350 )

cellular

abnormal sperm flagellum morphology ( J:326350 )

• bifid tails, loopings of the falgellum

abnormal sperm axoneme morphology ( J:326350 )

• disorganized microtubular structure, lacking of the regular 9+2 structure

short sperm flagellum ( J:326350 )

oligozoospermia ( J:326350 )

• very few spermatozoa and absence of mature sperm without an increase in oxidative stress or apoptotic events

abnormal sperm head morphology ( J:326350 )

abnormal acrosome morphology ( J:326350 )

• immature acrosomal structures

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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