Analysis Tools
neoplasm
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• 77.8% life-time incidence of follicular lymphoma
• lymphoma onset is first detected around 1 year of age
• in some mice, follicular lymphoma shows widespread organ involvement including the liver, mesenteric lymph nodes, inguinal lymph nodes, spleen, pancreas, and cervical lymph nodes
• high grade aggressive follicular lymphoma has characteristics of diffuse large B-cell lymphoma
• however, mice do not show increased incidence of epithelial cancers
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immune system
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• B cells are maintained in a less differentiated state
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced plasma cell differentiation
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced germinal center B cell formation
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• B cells accumulate at the G0/G1 phase of the cell cycle after 3 days of T cell-dependent activation thus there is an increased number of B cells in G0/G1 and fewer in S and G2/M
• B cells show a small but significant decrease in the levels of NAD+
• however, B cells do not alter mitochondrial oxidative phosphorylation after 24 hours of T cell-dependent activation
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• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show decreased IgG1 production, reduced germinal center B cell formation, and reduced plasma cell differentiation
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• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability
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hematopoietic system
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• B cells are maintained in a less differentiated state
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced plasma cell differentiation
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• mice show survival of CD45+ cells within the liver up to 3 months postnatally suggesting extramedullary hematopoiesis even after birth
• however, mature blood cell and hematopoietic stem progenitor cell (HSPC) numbers are normal, with no changes in T cells and B cells, numbers of macrophages, granulocytes, NK cells, and plasma cells, and normal levels of multipotent progenitor cells and
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced germinal center B cell formation
|
|
• B cells accumulate at the G0/G1 phase of the cell cycle after 3 days of T cell-dependent activation thus there is an increased number of B cells in G0/G1 and fewer in S and G2/M
• B cells show a small but significant decrease in the levels of NAD+
• however, B cells do not alter mitochondrial oxidative phosphorylation after 24 hours of T cell-dependent activation
|
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• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
|
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• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show decreased IgG1 production, reduced germinal center B cell formation, and reduced plasma cell differentiation
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• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability
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cellular
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• mouse embryonic fibroblasts (MEFs) exhibit increased levels of basal/maximum oxygen consumption, ATP production, and spare respiratory capacity
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• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
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• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| follicular lymphoma | DOID:0050873 |
OMIM:151430 |
J:324270 | |
