About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		A930024E05Rikem2Zfa
endonuclease-mediated mutation 2, Zusen Fan
MGI:7311693
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:7311733
cn2
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311734
cn3
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311735
cn4
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311736


Genotype
MGI:7311733
cn1
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:259392 )
N
• mice exhibit normal development of innate lymphoid cell progenitors

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells
• however, ILC1 and ILC2s numbers are normal




Genotype
MGI:7311734
cn2
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased susceptibility to bacterial infection ( J:259392 )
• in C. rodentium exposed mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation




Genotype
MGI:7311735
cn3
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, overexpression of Zfp292 rescues ILC3 proliferation




Genotype
MGI:7311736
cn4
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal interleukin secretion ( J:259392 )
• reduced IL22 secretion from intestinal lamina propria lymphocytes of C. rodentium exposed mice
increased susceptibility to bacterial infection ( J:259392 )
• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, increased mortality, reduced IL22-secreting cells in the intestine, and IL22 secretion from intestinal lamina propria compared with control mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, ILC1 and ILC2s numbers are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory