All Phenotypes Satb1<em1Zfa> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Satb1^em1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:7311696

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Satb1^em1Zfa/Satb1^em1Zfa	involves: C57BL/6	MGI:7311740
cn2	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311734
cn3	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311735

Allelic Composition	Satb1^em1Zfa/Satb1^em1Zfa
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:259392 )

• mice die 4 weeks after birth

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to impaired proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• in C. rodentium exposed mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, overexpression of Zfp292 rescues ILC3 proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24