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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Satb1em1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:7311696
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Satb1em1Zfa/Satb1em1Zfa involves: C57BL/6 MGI:7311740
cn2
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311734
cn3
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311735


Genotype
MGI:7311740
hm1
Allelic
Composition		 Satb1em1Zfa/Satb1em1Zfa
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:259392 )
• mice die 4 weeks after birth

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to impaired proliferation




Genotype
MGI:7311734
cn2
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased susceptibility to bacterial infection ( J:259392 )
• in C. rodentium exposed mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation




Genotype
MGI:7311735
cn3
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, overexpression of Zfp292 rescues ILC3 proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory