Phenotypes associated with this allele

• Allele Symbol: Sec61g^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:7311993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sec61g^em1(IMPC)J/Sec61g^em1(IMPC)J	C57BL/6NJ-Sec61g^em1(IMPC)J/Mmjax	MGI:7629092
ht2	Sec61g^em1(IMPC)J/Sec61g^+	C57BL/6NJ-Sec61g^em1(IMPC)J/Mmjax	MGI:7768422

Genotype
MGI:7629092

hm1

• Allelic Composition: Sec61g^em1(IMPC)J/Sec61g^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Sec61g^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Sec61g

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sec61g^em1(IMPC)J/Sec61g^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although early blastocysts are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:7768422

ht2

• Allelic Composition: Sec61g^em1(IMPC)J/Sec61g⁺
• Genetic Background: C57BL/6NJ-Sec61g^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Sec61g

behavior/neurological

tremors ( J:211773 )

IMPC - JAX

integument

abnormal coat/ hair morphology ( J:211773 )

♀

IMPC - JAX