mortality/aging
• fewer than expected mice are born
|
reproductive system
|
• disorganized
|
|
• reduced tubular epithelium height with increased number of multinucleated cells
|
|
• maturation defect
|
|
• in male mice
|
|
• asynchronized and delayed of the first wave of spermatogenesis due to delayed meiotic entry
|
|
• lower spermatid and spermatozoa production and reduced epididymal sperm count
|
|
• delayed meiotic entry during the first wave of spermatogenesis
|
growth/size/body
• fewer than expected mice are born
|
• at 2 and 15 weeks of age
|
liver/biliary system
• in female and male mice
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endocrine/exocrine glands
|
• disorganized
|
|
• reduced tubular epithelium height with increased number of multinucleated cells
|
|
• maturation defect
|
|
• in male mice
|
cellular
|
• lower spermatid and spermatozoa production and reduced epididymal sperm count
|
|
• delayed meiotic entry during the first wave of spermatogenesis
|