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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxo38em1Crmk
endonuclease-mediated mutation 1, Lukas Cermak
MGI:7311994
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxo38em1Crmk/Fbxo38em1Crmk C57BL/6N-Fbxo38em1Crmk MGI:7312025


Genotype
MGI:7312025
hm1
Allelic
Composition		 Fbxo38em1Crmk/Fbxo38em1Crmk
Genetic
Background		 C57BL/6N-Fbxo38em1Crmk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo38em1Crmk mutation (0 available); any Fbxo38 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:326445 )
• fewer than expected mice are born

reproductive system
abnormal seminiferous tubule epithelium morphology ( J:326445 )
• reduced tubular epithelium height with increased number of multinucleated cells
abnormal Sertoli cell development ( J:326445 )
• maturation defect
decreased testis weight ( J:326445 )
• in male mice
abnormal spermatogenesis ( J:326445 )
• asynchronized and delayed of the first wave of spermatogenesis due to delayed meiotic entry
oligozoospermia ( J:326445 )
• lower spermatid and spermatozoa production and reduced epididymal sperm count
abnormal male meiosis ( J:326445 )
• delayed meiotic entry during the first wave of spermatogenesis

growth/size/body
decreased birth body size ( J:326445 )
• fewer than expected mice are born
decreased birth weight ( J:326445 )
decreased body weight ( J:326445 )
• at 2 and 15 weeks of age
decreased body length ( J:326445 )

liver/biliary system
decreased liver weight ( J:326445 )
• in female and male mice

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:326445 )
• reduced tubular epithelium height with increased number of multinucleated cells
abnormal Sertoli cell development ( J:326445 )
• maturation defect
decreased testis weight ( J:326445 )
• in male mice

cellular
oligozoospermia ( J:326445 )
• lower spermatid and spermatozoa production and reduced epididymal sperm count
abnormal male meiosis ( J:326445 )
• delayed meiotic entry during the first wave of spermatogenesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory