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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp4r3aem1Qili
endonuclease-mediated mutation 1, Qiji Liu
MGI:7312039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp4r3aem1Qili/Ppp4r3aem1Qili
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas * C57BL/6J MGI:7312047


Genotype
MGI:7312047
cn1
Allelic
Composition		 Ppp4r3aem1Qili/Ppp4r3aem1Qili
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Ppp4r3aem1Qili mutation (0 available); any Ppp4r3a mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:326388 )
N
• mice exhibit normal spatial learning and memory skills
abnormal sucrose solution preference ( J:326388 )
• decreased sucrose preference
behavioral despair ( J:326388 )
• increased immobility time in a tail suspension test and open field test
increased anxiety-related response ( J:326388 )
• reduced exploration of open arms in an elevated plus maze

nervous system
decreased dendritic spine density ( J:326388 )
• in the hippocampus
abnormal miniature excitatory postsynaptic currents ( J:326388 )
• reduced frequency and amplitude
decreased neurotransmitter release ( J:326388 )
• decreased glutamate release




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory