About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp4r3aem1Qili
endonuclease-mediated mutation 1, Qiji Liu
MGI:7312039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp4r3aem1Qili/Ppp4r3aem1Qili
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas * C57BL/6J MGI:7312047


Genotype
MGI:7312047
cn1
Allelic
Composition		 Ppp4r3aem1Qili/Ppp4r3aem1Qili
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Ppp4r3aem1Qili mutation (0 available); any Ppp4r3a mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:326388 )
N
• mice exhibit normal spatial learning and memory skills
abnormal sucrose solution preference ( J:326388 )
• decreased sucrose preference
behavioral despair ( J:326388 )
• increased immobility time in a tail suspension test and open field test
increased anxiety-related response ( J:326388 )
• reduced exploration of open arms in an elevated plus maze

nervous system
decreased dendritic spine density ( J:326388 )
• in the hippocampus
abnormal miniature excitatory postsynaptic currents ( J:326388 )
• reduced frequency and amplitude
decreased neurotransmitter release ( J:326388 )
• decreased glutamate release




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory