Phenotypes associated with this allele

• Allele Symbol: Cd82^tm1Kjbr
• Allele Name: targeted mutation 1, Katrina J Binger
• Allele ID: MGI:7312064
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd82^tm1Kjbr/Cd82^tm1Kjbr	Not Specified	MGI:7312067

Genotype
MGI:7312067

hm1

• Allelic Composition: Cd82^tm1Kjbr/Cd82^tm1Kjbr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1

increased neutrophil cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model

increased macrophage cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model and in response to oxygen-induced retinopathy

abnormal neutrophil physiology ( J:326451 )

• increased neutrophil migration in response to CXCL1 or LTB4

increased susceptibility to bacterial infection ( J:326451 )

• L. Mexicana-infected mice exhibit increased infiltration of myeloid cells and increased size and persistence of lesions that persist longer than 11 weeks compared with wild-type mice

vision/eye

increased susceptilbility to retina ischemic injury ( J:326451 )

• increased myeloid cell migration and retinal inflammation in response to oxygen-induced retinopathy

hematopoietic system

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1

increased neutrophil cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model

increased macrophage cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model and in response to oxygen-induced retinopathy

abnormal neutrophil physiology ( J:326451 )

• increased neutrophil migration in response to CXCL1 or LTB4

homeostasis/metabolism

increased susceptilbility to retina ischemic injury ( J:326451 )

• increased myeloid cell migration and retinal inflammation in response to oxygen-induced retinopathy

cellular

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1