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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsdmaem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7312160
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsdmaem1Cya/Gsdmaem1Cya C57BL/6J-Gsdmaem1Cya MGI:7312171


Genotype
MGI:7312171
hm1
Allelic
Composition		 Gsdmaem1Cya/Gsdmaem1Cya
Genetic
Background		 C57BL/6J-Gsdmaem1Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdmaem1Cya mutation (0 available); any Gsdma mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:326434 )
• mice infected with SpeB exhibit uncontrolled bacterial dissemination and death compared with wild-type mice

immune system
increased susceptibility to bacterial infection ( J:326434 )
• keratinocytes electroporated with recombinant SpeB do not exhibit pyroptosis unlike in wild-type mice
• mice infected with SpeB exhibit uncontrolled bacterial dissemination and death compared with wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:326434 )
• mice infected with SpeB exhibit uncontrolled bacterial dissemination and death compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory