Phenotypes associated with this allele

• Allele Symbol: Cry1^em1Liga
• Allele Name: endonuclease-mediated mutation 1, Gang Li
• Allele ID: MGI:7314236
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cry1^em1Liga/Cry1^em1Liga	involves: C57BL/6	MGI:7314237

Genotype
MGI:7314237

hm1

• Allelic Composition: Cry1^em1Liga/Cry1^em1Liga
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:323111 )

♂N • adult males show no significant reduction in testes and epididymis weights and exhibit normal Sertoli and Leydig cells relative to wild-type controls

increased male germ cell apoptosis ( J:323111 )

♂ • TUNEL staining showed a significantly higher number of TUNEL+ apoptotic germ cells than in wild-type testes

abnormal seminiferous tubule morphology ( J:323111 )

♂ • at 4 months of age, H&E staining showed significantly more degenerated germ cells in the seminiferous tubules than in wild-type controls

abnormal testis physiology ( J:323111 )

♂ • testes show altered expression of genes involved in cell communication, chromatin reorganization, spermatogenesis, and immune response

♂ • testicular mRNA levels of Per2 (period circadian clock 2) are higher than in wild-type testes, whereas no differences are observed in the expression of other clock genes

abnormal spermatogenesis ( J:323111 )

♂

oligozoospermia ( J:323111 )

♂ • at 4 months of age, cauda epididymal sperm count is significantly lower than in wild-type controls

cellular

oligozoospermia ( J:323111 )

♂ • at 4 months of age, cauda epididymal sperm count is significantly lower than in wild-type controls

increased male germ cell apoptosis ( J:323111 )

♂ • TUNEL staining showed a significantly higher number of TUNEL+ apoptotic germ cells than in wild-type testes

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:323111 )

♂ • at 4 months of age, H&E staining showed significantly more degenerated germ cells in the seminiferous tubules than in wild-type controls

abnormal testis physiology ( J:323111 )

♂ • testes show altered expression of genes involved in cell communication, chromatin reorganization, spermatogenesis, and immune response

♂ • testicular mRNA levels of Per2 (period circadian clock 2) are higher than in wild-type testes, whereas no differences are observed in the expression of other clock genes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:323111 )

♂N • adult males have normal serum and intratesticular testosterone levels relative to wild-type controls