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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mptx2em1Yoxi
endonuclease-mediated mutation 1, Yongtao Xiao
MGI:7314446
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mptx2em1Yoxi/Mptx2em1Yoxi C57BL/6J-Mptx2em1Yoxi MGI:7314456


Genotype
MGI:7314456
hm1
Allelic
Composition		 Mptx2em1Yoxi/Mptx2em1Yoxi
Genetic
Background		 C57BL/6J-Mptx2em1Yoxi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mptx2em1Yoxi mutation (0 available); any Mptx2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:326562 )
• mice exhibit increased susceptibility to methicillin-resistant Staphylococcus aureus (MRSA) infection, showing increased MRSA loading in the blood, peritoneal lavage, liver, kidney, and spleen, more severe histologic injury, increased serum levels of aspartate aminotransferase, alanine aminotransferase, creatine and blood urea nitrogen, and increased mRNA levels of inflammatory genes in the liver, kidney, spleen and distal small intestine




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory