Phenotypes associated with this allele

• Allele Symbol: Tcfl5^tm1Frem
• Allele Name: targeted mutation 1, Manuel Fresno
• Allele ID: MGI:7316451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tcfl5^tm1Frem/Tcfl5^tm1Frem Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA	MGI:7316744

Genotype
MGI:7316744

cn1

• Allelic Composition: Tcfl5^tm1Frem/Tcfl5^tm1Frem; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:326601 )

♂ • adult tamoxifen-treated males lack spermatozoa in the seminiferous tubule lumen

abnormal spermatid morphology ( J:326601 )

♂ • adult tamoxifen-treated males show alterations in spermatid elongation resulting in aberrant spermatid morphology

multinucleated giant male germ cells ( J:326601 )

♂ • adult tamoxifen-treated males exhibit multinucleated round giant cells containing primary spermatocytes in most seminiferous tubules

arrest of male meiosis ( J:326601 )

♂

abnormal seminiferous tubule morphology ( J:326601 )

♂ • adult tamoxifen-treated males show abnormal tubule morphology features, including multinucleated rounded giant cells containing primary spermatocytes, a decreased number of elongated spermatids, and no spermatozoa in the lumen

small testis ( J:326601 )

♂ • adult tamoxifen-treated males exhibit a significantly smaller testis size than control males

decreased testis weight ( J:326601 )

♂ • adult tamoxifen-treated males exhibit a significantly lower testis weight than control males

abnormal spermiogenesis ( J:326601 )

♂ • adult tamoxifen-treated males show a 4.5-fold increase in the % of elongated spermatids with aberrant morphology relative to non-treated control males

male infertility ( J:326601 )

♂

cellular

azoospermia ( J:326601 )

♂ • adult tamoxifen-treated males lack spermatozoa in the seminiferous tubule lumen

abnormal spermatid morphology ( J:326601 )

♂ • adult tamoxifen-treated males show alterations in spermatid elongation resulting in aberrant spermatid morphology

multinucleated giant male germ cells ( J:326601 )

♂ • adult tamoxifen-treated males exhibit multinucleated round giant cells containing primary spermatocytes in most seminiferous tubules

arrest of male meiosis ( J:326601 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:326601 )

♂ • adult tamoxifen-treated males show abnormal tubule morphology features, including multinucleated rounded giant cells containing primary spermatocytes, a decreased number of elongated spermatids, and no spermatozoa in the lumen

small testis ( J:326601 )

♂ • adult tamoxifen-treated males exhibit a significantly smaller testis size than control males

decreased testis weight ( J:326601 )

♂ • adult tamoxifen-treated males exhibit a significantly lower testis weight than control males