Phenotypes associated with this allele

• Allele Symbol: Katnal2^em1Zhlu
• Allele Name: endonuclease-mediated mutation 1, Zhongxian Lu
• Allele ID: MGI:7316544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Katnal2^em1Zhlu/Katnal2^em1Zhlu	C57BL/6-Katnal2^em1Zhlu	MGI:7316546

Genotype
MGI:7316546

hm1

• Allelic Composition: Katnal2^em1Zhlu/Katnal2^em1Zhlu
• Genetic Background: C57BL/6-Katnal2^em1Zhlu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:322392 )

♂ • epididymal sperm count is significantly lower than in wild-type males

teratozoospermia ( J:322392 )

♂ • H&E staining of testis sections and Papanicolaou staining of epididymal sperm showed severe sperm morphological abnormalities, esp. of the sperm heads

abnormal sperm head morphology ( J:322392 )

♂ • sperm exhibit severely deformed heads

asthenozoospermia ( J:322392 )

♂ • sperm motility rate (%) is almost reduced to zero

abnormal spermiogenesis ( J:322392 )

♂

abnormal epididymis morphology ( J:322392 )

• H&E staining showed a significantly reduced sperm number in the epididymal cavity

male infertility ( J:322392 )

♂

cellular

oligozoospermia ( J:322392 )

♂ • epididymal sperm count is significantly lower than in wild-type males

teratozoospermia ( J:322392 )

♂ • H&E staining of testis sections and Papanicolaou staining of epididymal sperm showed severe sperm morphological abnormalities, esp. of the sperm heads

abnormal sperm head morphology ( J:322392 )

♂ • sperm exhibit severely deformed heads

asthenozoospermia ( J:322392 )

♂ • sperm motility rate (%) is almost reduced to zero