Phenotypes associated with this allele

• Allele Symbol: Stmp1^em1Eno
• Allele Name: endonuclease-mediated mutation 1, Eric N Olson
• Allele ID: MGI:7327130
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stmp1^em1Eno/Stmp1^em1Eno	C57BL/6-Stmp1^em1Eno	MGI:7327140

Genotype
MGI:7327140

hm1

• Allelic Composition: Stmp1^em1Eno/Stmp1^em1Eno
• Genetic Background: C57BL/6-Stmp1^em1Eno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:325962 )

N • mice do not exhibit an overt phenotype, showing normal heart function and cardiac dimensions

abnormal cardiovascular system physiology ( J:325962 )

• hearts show an increase in alpha-ketoglutarate

• hearts show an increase in the glycolytic endpoints of pyruvate, lactate, and aceteyl-CoA and an increase in pentose phosphate

cellular

abnormal respiratory electron transport chain ( J:325962 )

• cardiac mitochondria show disruption of complex III assembly into supercomplexes

• cardiac tissue respirating mitochondria show reduced complex III activity

• isolated mitochondria from hearts show reduced rates of pyruvate-driven respiration and a reduction in succinate oxidation