Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-1810058I24Rik)#Eno
• Allele Name: transgene insertion, Eric N Olson
• Allele ID: MGI:7327134
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-1810058I24Rik)#Eno/0	involves: C57BL/6	MGI:7327138

Genotype
MGI:7327138

tg1

• Allelic Composition: Tg(Myh6-1810058I24Rik)#Eno/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:325962 )

• cardiomyopathy leading to premature death by 6 months of age

cardiovascular system

abnormal heart morphology ( J:325962 )

• heart muscle shows mitochondrial abnormalities, including alterations in inner mitochondrial membrane cristae morphology and mitochondrial disorganization

increased heart weight ( J:325962 )

• mice exhibit increased heart weight by 2 months of age

cardiac hypertrophy ( J:325962 )

• hearts show hypertrophy with activation of the fetal gene program

cardiac interstitial fibrosis ( J:325962 )

• a low level of diffuse interstitial fibrosis is seen throughout the heart of 2-month-old mice

decreased cardiac muscle contractility ( J:325962 )

• mice exhibit a progressive reduction in fractional shortening at 1 to 6 months of age

abnormal heart echocardiography feature ( J:325962 )

• echocardiography of left ventricular function shows increased left ventricular internal diameter during both diastole and systole at 2 and 6 months of age, decreased left ventricular posterior wall thickness during both diastole and systole, and reduced fractional shortening at 1, 2, and 6 months of age indicating that mice show early signs of cardiomyopathy by weaning age (1 month) which progresses to severe heart failure by 6 months of age

cardiomyopathy ( J:325962 )

congestive heart failure ( J:325962 )

• heart failure by 6 months of age

cellular

cardiac interstitial fibrosis ( J:325962 )

• a low level of diffuse interstitial fibrosis is seen throughout the heart of 2-month-old mice

abnormal mitochondrial morphology ( J:325962 )

• heart muscle shows mitochondrial abnormalities, including alterations in inner mitochondrial membrane cristae morphology and mitochondrial disorganization

abnormal mitochondrial physiology ( J:325962 )

• cardiac mitochondria shows a reduction in total NADH oxidase activity

• cardiac extracts show reductions in protein levels of complex I, complex IV, and complex V and the reactive oxygen species scavenger protein glutathione peroxidase 4

• however, heart mitochondria does not show altered complex III activity and no changes in mitochondrial supercomplex formation or stability

oxidative stress ( J:325962 )

• heart tissues shows reduced ratio of glutathione to oxidized glutathione, suggesting a high level oxidative stress in hearts

growth/size/body

increased heart weight ( J:325962 )

• mice exhibit increased heart weight by 2 months of age

cardiac hypertrophy ( J:325962 )

• hearts show hypertrophy with activation of the fetal gene program

increased lung weight ( J:325962 )

• mice exhibit increased lung weight by 2 months of age

homeostasis/metabolism

abnormal atrial thrombosis ( J:325962 )

• large left atrial thrombi are commonly seen at 6 months of age

muscle

decreased cardiac muscle contractility ( J:325962 )

• mice exhibit a progressive reduction in fractional shortening at 1 to 6 months of age

cardiomyopathy ( J:325962 )

respiratory system

increased lung weight ( J:325962 )

• mice exhibit increased lung weight by 2 months of age