Phenotypes associated with this allele

• Allele Symbol: Slitrk2^tm1.1Jaru
• Allele Name: targeted mutation 1.1, Jun Aruga
• Allele ID: MGI:7327302
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slitrk2^tm1.1Jaru/Slitrk2^tm1.1Jaru	B6.129P2-Slitrk2^tm1.1Jaru	MGI:7327387

Genotype
MGI:7327387

hm1

• Allelic Composition: Slitrk2^tm1.1Jaru/Slitrk2^tm1.1Jaru
• Genetic Background: B6.129P2-Slitrk2^tm1.1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:326787 )

• lower freezing response

decreased exploration in new environment ( J:326787 )

• decreased latency to investigate the hole in a hole board test

abnormal sucrose solution preference ( J:326787 )

• increased sucrose preference

increased coping response ( J:326787 )

• decreased immobility time in tail suspension and forced swim test

• however, lithium treatment decreases immobility time in tail suspension and forced swim test

increased thigmotaxis ( J:326787 )

• in an open field test

abnormal vestibuloocular reflex ( J:326787 )

• increased vestibuloocular reflex

enhanced coordination ( J:326787 )

• increased latency to falling off a rotarod despite extra movements

hyperactivity ( J:326787 )

• in an open field test during the light and early dark phases as well as in the elevated plus maze test, light-box test, marble burying test, hole board test, and social preference test

• lithium treatment does not reduce hyperactivity

• however, methylphenidate treatment increased while Chronic fluoxetine administration reduces hyperactivity as in wild-type mice

nervous system

nervous system phenotype ( J:326787 )

N • mice exhibit normal input-output relation- ship, paired-pulse ratio, and long-term potentiation

N • mice exhibit normal length, width, and density of dendritic spines

abnormal serotonergic neuron morphology ( J:326787 )

• decreased numbers in the dorsal raphe nucleus

abnormal synapse morphology ( J:326787 )

• mildly affected with greater distance between synaptic vesicles and slightly increased synaptic cleft

abnormal excitatory postsynaptic potential ( J:326787 )

• increased percent increase at 1 Hz

• decreased percent increase in EPSP induced by serotonin

• however, EPSP is normal at 0.2 Hz and 2 Hz

hearing/vestibular/ear

abnormal vestibuloocular reflex ( J:326787 )

• increased vestibuloocular reflex

homeostasis/metabolism

abnormal dopamine level ( J:326787 )

• increased homovanillic acid levels in the hippocampus, but not the striatum and nucleus accumbens

abnormal serotonin level ( J:326787 )

• increased 5-hydroxyindoleacetic acid levels in the hippocampus and amygdala indicating higher serotonin turnover