All Phenotypes Aldh1a2<tm1.1Mbp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aldh1a2^tm1.1Mbp
targeted mutation 1.1, Mouse Biology Program, UC Davis
MGI:7327620

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺	involves: 129 * C57BL/6 * SJL	MGI:7327644
cn2	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.1Mbp Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:7327640
cn3	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Tg(Stra8-icre)1Reb/0	involves: 129 * C57BL/6 * FVB/NJ	MGI:7327642

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1^tm1Gdu mutation (1 available); any Aldh1a1 mutation (39 available)
Aldh1a2^tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (38 available)
Aldh1a2^tm1.2Mbp mutation (0 available); any Aldh1a2 mutation (38 available)
Plekha5^{Tg(AMH-cre)1Flor} mutation (1 available); any Plekha5 mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased Sertoli cell number ( J:324715 )

abnormal spermatogenesis ( J:324715 )

• block at the progression at the conversion of A spermatogonia to A1

• however, injection with retinoic acid restored spermatogenesis

azoospermia ( J:324715 )

male infertility ( J:324715 )

endocrine/exocrine glands

decreased Sertoli cell number ( J:324715 )

cellular

azoospermia ( J:324715 )

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.1Mbp Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1^tm1Gdu mutation (1 available); any Aldh1a1 mutation (39 available)
Aldh1a2^tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (38 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:324715 )

• block at the progression at the conversion of A spermatogonia to A1 following chronic treatment with tamoxifen

azoospermia ( J:324715 )

• sperm depletion occurs after chronic administration of tamoxifen

male infertility ( J:324715 )

cellular

azoospermia ( J:324715 )

• sperm depletion occurs after chronic administration of tamoxifen

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Tg(Stra8-icre)1Reb/0
Genetic Background	involves: 129 * C57BL/6 * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:324715 )

N	• male mice exhibit normal spermatogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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