All Phenotypes Mfn2<em1Cya> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mfn2^em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7327650

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mfn2^em1Cya/Mfn2^em1Cya Tg(Stra8-icre)1Reb/0	involves: C57BL/6J * FVB/NJ	MGI:7327651

Allelic Composition	Mfn2^em1Cya/Mfn2^em1Cya Tg(Stra8-icre)1Reb/0
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2^em1Cya mutation (1 available); any Mfn2 mutation (27 available)
Tg(Stra8-icre)1Reb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:324164 )

• spermatocytes exhibit aggregation of mitochondria with disrupted respiratory chain compared with control cells

kinked sperm flagellum ( J:324164 )

• folded or broken tails

abnormal sperm nucleus morphology ( J:324164 )

abnormal male meiosis ( J:324164 )

• abnormal progression from the zygotene to pachytene stages and impaired crossing over

small seminiferous tubules ( J:324164 )

• reduced diameter

small testis ( J:324164 )

endocrine/exocrine glands

small seminiferous tubules ( J:324164 )

• reduced diameter

small testis ( J:324164 )

cellular

abnormal sperm mitochondrial sheath morphology ( J:324164 )

• spermatocytes exhibit aggregation of mitochondria with disrupted respiratory chain compared with control cells

kinked sperm flagellum ( J:324164 )

• folded or broken tails

abnormal sperm nucleus morphology ( J:324164 )

abnormal male meiosis ( J:324164 )

• abnormal progression from the zygotene to pachytene stages and impaired crossing over

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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