Phenotypes associated with this allele

• Allele Symbol: Stox1^tm1Rkl
• Allele Name: targeted mutation 1, Raghu Kalluri
• Allele ID: MGI:7328383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stox1^tm1Rkl/Stox1^tm1Rkl	129-Stox1^tm1Rkl	MGI:7328394

Genotype
MGI:7328394

hm1

• Allelic Composition: Stox1^tm1Rkl/Stox1^tm1Rkl
• Genetic Background: 129-Stox1^tm1Rkl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal pregnancy ( J:308988 )

♀ • mice develop gestational hypertension

cardiovascular system

abnormal glomerular capillary endothelium morphology ( J:308988 )

♀ • the glomerular filtration barrier of kidneys from pregnant mice shows prominent endothelial cells but no evidence of glomerular endotheliosis

abnormal placenta vasculature ( J:308988 )

• a higher density of CD31+ vessels is seen in the decidua of placentas

• losartan treatment of pregnant mice starting at E14.5 ameliorates the microscopic vascular placenta abnormalities

increased susceptibility to hypertension ( J:308988 )

♀ • mice develop gestational hypertension; systolic blood pressure increases with gestational age among pregnant mice and is significantly elevated at E17.5

♀ • however, postpartum, blood pressure normalization occurs

♀ • pregnant mice treated with the angiotensin II receptor blocker losartan starting at E14.5 show normalization of blood pressure to wild-type levels

embryo

embryo phenotype ( J:308988 )

N • weights of embryos and placentas at E17.5 are similar to wild-type litters and no differences in placental architecture, trophoblast morphology in the junctional zone, or labyrinth layers are seen

abnormal placenta morphology ( J:308988 )

• placentas show higher renin levels

• extracellular matrix proteins laminin, nidogen-1, and type IV collage alpha1 are increased in the junctional zone and decidua of placenta

• losartan treatment of pregnant mice starting at E14.5 ameliorates the basement membrane abnormalities seen in placentas

abnormal placenta vasculature ( J:308988 )

• a higher density of CD31+ vessels is seen in the decidua of placentas

• losartan treatment of pregnant mice starting at E14.5 ameliorates the microscopic vascular placenta abnormalities

abnormal placenta physiology ( J:308988 )

• pregnant mice injected with hypoxyprobe at E17.5 show increased staining for hypoxyprobe in the junctional zone indicating some placental hypoxia by late gestation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308988 )

♀N • no differences in proteinuria are seen between nonpregnant and pregnant mice

renal/urinary system

abnormal glomerular capillary endothelium morphology ( J:308988 )

♀ • the glomerular filtration barrier of kidneys from pregnant mice shows prominent endothelial cells but no evidence of glomerular endotheliosis

abnormal podocyte foot process morphology ( J:308988 )

♀ • the glomerular filtration barrier of kidneys from pregnant mice shows rare areas containing edematous podocyte foot processes but no evidence of podocyte foot process effacement