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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ramacem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:7328450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ramacem1(IMPC)J/Ramacem1(IMPC)J C57BL/6NJ-Ramacem1(IMPC)J/Mmjax MGI:7551202
ht2
 		Ramacem1(IMPC)J/Ramac+ C57BL/6NJ-Ramacem1(IMPC)J/Mmjax MGI:7551201


Genotype
MGI:7551202
hm1
Allelic
Composition		 Ramacem1(IMPC)J/Ramacem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Ramacem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ramacem1(IMPC)J mutation (2 available); any Ramac mutation (12 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ramacem1(IMPC)J/Ramacem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show severe developmental delay as small egg cylinders, poorly organized extraembryonic tissues and failure of gastrulation.

embryo
failure to gastrulate ( J:279207 )
• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5
decreased egg cylinder size ( J:279207 )
• a small egg cylinder is observed at E7.5
failure of primitive streak formation ( J:279207 )
• no Brachyury (T)-positive cells are present at E7.5
disorganized extraembryonic tissue ( J:279207 )
• extraembryonic tissues are poorly organized at E7.5

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present at E7.5 (8% versus expected 25%, n=24); no homozygous embryos are recovered at E9.5




Genotype
MGI:7551201
ht2
Allelic
Composition		 Ramacem1(IMPC)J/Ramac+
Genetic
Background		 C57BL/6NJ-Ramacem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ramacem1(IMPC)J mutation (2 available); any Ramac mutation (12 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory