Phenotypes associated with this allele

• Allele Symbol: Kcnt1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:7328749
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnt1^tm1Dgen/Kcnt1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:7450812

Genotype
MGI:7450812

hm1

• Allelic Composition: Kcnt1^tm1Dgen/Kcnt1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:333464 )

N • normal total distance traveled in elevated plus maze (EPM) and travel velocity in open field test (OFT)

N • normal behavior in forced swim test (FST), sucrose preference test (SPT) and tail suspension test (TST)

N • normal behavior in cued fear conditioning test

increased thigmotaxis ( J:333464 )

• in open field test (OFT) and elevated plus maze (EPM)

nervous system

nervous system phenotype ( J:333464 )

N • normal slow afterhyperpolarization in basolateral amygdala glutamatergic neurons

abnormal nervous system electrophysiology ( J:333464 )

• higher resting potential in basolateral amygdala excitatory neurons

abnormal action potential ( J:333464 )

• 2x more action potentials in response to depolarization current in basolateral amygdala glutamatergic neurons