Analysis Tools
cellular
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• redistribution of mitochondria in the perinuclear region of fully-grown germinal vesicle-intact (GV) oocytes
• GV oocytes show smaller mitochondrial cluster size and mitochondria appears more dispersed than clustered
• MII eggs show a similar mitochondria redistribution defect but to a lesser extent
• however, mitochondria number, ultrastructure and ATP levels in oocytes are normal
• however, fully-grown GV oocytes appear normal and meiotic maturation of oocytes appears normal
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reproductive system
| N |
• fertility is unaffected and average litter size of breeding homozygous females with homozygous males or with wild-type males is normal
• while breeding pairs that are continuously mated produce the first litter on average two weeks later than wild-type mice, seem to have a slightly lower (approximately one pup) cumulative litter size until about 20 weeks of age (this difference is not significant in mice under 16 weeks of age), and two of four breeding pairs stop producing progeny around 30 weeks of age compared to around 40 weeks for wild-type mice, no significant effect on the litter size is seen when all matings are stratified according to female age, indicting unaffected fertility
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• redistribution of mitochondria in the perinuclear region of fully-grown germinal vesicle-intact (GV) oocytes
• GV oocytes show smaller mitochondrial cluster size and mitochondria appears more dispersed than clustered
• MII eggs show a similar mitochondria redistribution defect but to a lesser extent
• however, mitochondria number, ultrastructure and ATP levels in oocytes are normal
• however, fully-grown GV oocytes appear normal and meiotic maturation of oocytes appears normal
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